GW26-e0804 Human cardiosphere-derived cells from advanced heart failure patients improve ventricular function in myocardial infarction
نویسندگان
چکیده
منابع مشابه
Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair.
OBJECTIVES This study sought to compare the regenerative potency of cells derived from healthy and diseased human hearts. BACKGROUND Results from pre-clinical studies and the CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial support the notion that cardiosphere-derived cells (CDCs) from normal and recently infarcted hearts are capable of regenerati...
متن کاملMesenchymal stem cells from ischemic heart disease patients improve left ventricular function after acute myocardial infarction.
Mesenchymal stem cells (MSCs) from healthy donors improve cardiac function in experimental acute myocardial infarction (AMI) models. However, little is known about the therapeutic capacity of human MSCs (hMSCs) from patients with ischemic heart disease (IHD). Therefore, the behavior of hMSCs from IHD patients in an immune-compromised mouse AMI model was studied. Enhanced green fluorescent prote...
متن کاملIntramyocardial injection of heart-derived extracellular matrix combined with cardiosphere-derived cells improves myocardial structure and function in rats with acute myocardial infarction
This study aimed to investigate the cardioprotective effects of intramyocardial injection of heart derived extracellular matrix (ECM) and cardiosphere-derived cells (CDCs) in a rat model of myocardial infarction (MI). ECM and CDCs were collected from the rat heart, and the proliferation, apoptosis and morphology of CDCs maintained on ECM were characterized in vitro. MI model was established in ...
متن کاملCardiosphere-derived cells for heart regeneration.
www.thelancet.com Vol 379 June 30, 2012 2425 2 Lemos B, Araripe LO, Hartl DL. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science 2008; 319: 91–93. 3 Lemos B, Branco AT, Hartl DL. Epigenetic eff ects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual confl ict. Proc Natl Acad Sci USA 2010; 107: 15826–31. 4 Spach ...
متن کاملMagnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction.
RATIONALE The success of cardiac stem cell therapies is limited by low cell retention, due at least in part to washout via coronary veins. OBJECTIVE We sought to counter the efflux of transplanted cells by rendering them magnetically responsive and imposing an external magnetic field on the heart during and immediately after injection. METHODS AND RESULTS Cardiosphere-derived cells (CDCs) w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2015
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2015.06.1269